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Just how do cytoplasmic aspects controls integrin conformation?

Just how do cytoplasmic aspects controls integrin conformation? Integrin conformation-function relations: a model. A five-component design showing conformational variations that are involving inside-out and outside-in integrin signalling. The I±-subunit is during red plus the I?-subunit in blue. The figure shows the 3 major conformational states which have been determined to date: sedentary (A), primed (B) Just how do cytoplasmic aspects controls integrin conformation?